One of the most exciting areas of modern oncology is personalised – precision – oncology, which utilises genomic profiling of patient’s tumour to identify mutations and genetic alterations driving tumour cell replication and progression. This modern technology identifies “druggable targets” which can be then inactivated by targeted therapies that are often more effective with significantly less side effects than classical methods such as chemotherapy. Some of these new treatments are taking our patients’ survival into previously unheard territories, allowing them to enjoy close to normal lives for many years. This new technology also allows more accurate understanding of particular cancer behaviour, manifestation, and better prognostication, as well as strategic approach to further treatment at progression or relapse.